Familial Medullary Thyroid Carcinoma: Unveiling the Genetic Blueprint
Cancer of the thyroid's parafollicular C cells can run in families through RET mutations, including the rare M918V variant reported in Brazilian families.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Familial Partial Lipodystrophy, Dunnigan Type: The Role of Genetic Testing in Diagnosis and Management
A single altered copy of LMNA is enough to cause this autosomal dominant fat-distribution disorder, which brings insulin resistance, diabetes and dyslipidemia.
Hecht Syndrome: Harnessing Genetic Testing for a Brighter Future
Unlock insights into Hecht syndrome with genetic testing. Early diagnosis aids management, family planning, and personalized care. Explore advancements today.
Harnessing Genetic Testing in the Battle Against Hereditary Leiomyomatosis and Renal Cell Cancer
Fumarate builds up when the fumarate hydratase (FH) gene is mutated, predisposing to skin and uterine leiomyomas and an aggressive renal cell cancer in HLRCC.
Harnessing Genetic Insights: Diagnosing Hereditary Lymphedema Type I
Also called Milroy disease, hereditary lymphedema type I follows FLT4 mutations that disrupt lymphatic development and cause swelling, usually in the legs.
Harnessing Genetic Insights: A Deep Dive into Holoprosencephaly 2
Disruption of TGF-β, hedgehog and FGF signaling during embryonic development underlies this malformation, which prenatal screening can sometimes detect early.
Hyperekplexia 1: Early Diagnosis and GLRA1 Mutations
Startle disease type 1 is often hereditary through GLRA1 mutations. Confirming it in infancy supports clonazepam use, genetic counseling and family planning choices.
Harnessing Genetic Insights: Understanding Hypogonadotropic Hypogonadism 2 with or without Anosmia
Novel FGFR1 mutations found in Eastern Indian patients point to a varied genetic picture, where skeletal abnormalities accompany delayed puberty and infertility.