Premature Chromatid Separation Trait: Unraveling the Genetic Threads of a Rare Disorder
Early chromatid separation is a chromosomal instability syndrome tied to infertility, developmental delays and cancer risk, often missed without genetic testing.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Revolutionizing Retinal Detachment: The Role of Genetic Testing
Sudden flashes, floaters and a shadow across the visual field signal a detached retina; FEVR-linked mutations found in Pakistani families explain congenital cases.
Understanding 46,XY Sex Reversal 4: The Role of Genetic Testing in Diagnosis and Management
A missense change in SRY blocks nuclear transport, so a person with XY chromosomes develops female characteristics, gonadal dysgenesis and primary amenorrhea.
Age-Related Macular Degeneration 2: Understanding the Genetic Blueprint
Common and rare variants shape who develops AMD2, and work in Asian populations shows genetic predisposition differs by ethnicity, which affects risk assessment.
Angioosteohypertrophic Syndrome: Signs and Testing
Abnormal blood vessels, bone overgrowth and soft tissue hypertrophy can cause limb asymmetry and pain; genetic testing may support diagnosis and counseling.
Ataxia-Pancytopenia Syndrome: Unlocking Mysteries with Genetic Testing
Loss of movement coordination together with low blood counts points to SAMD9L mutations, which can also bring immunodeficiency and myelodysplastic syndrome.
Autosomal Dominant Childhood-Onset Proximal Spinal Muscular Atrophy: Genetic Insights and Implications
Motor neuron degeneration in the spinal cord brings weakness and atrophy, and dominant mutations, not only recessive ones, can cause childhood-onset proximal SMA.
Autosomal Dominant Keratitis: Unraveling the Genetic Threads of a Complex Condition
Progressive corneal degeneration and varying vision loss define ADK, which has been linked to GJB2. Testing tells it apart from other corneal diseases.