Cytogenetic Tests That Confirm PCS Trait
Molecular genetic tests and karyotyping can confirm the early parting of sister chromatids, giving a precise diagnosis and a measure of risk carried in a family.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Repeated Miscarriage and PCS Trait: When to Test
Couples facing repeated miscarriage or infertility with no found cause may be offered chromosome analysis, after which assisted reproduction can be considered.
Premature Chromatid Separation Trait Beyond Infertility
Errors in chromosome segregation reach past fertility: developmental disorders and certain cancers are linked too, which argues for monitoring after diagnosis.
Why a PCS Trait Diagnosis Needs Genetic Analysis
Subtle chromosomal changes make the trait hard to pin down with routine methods; a precise analysis of chromosome structure and behavior is what confirms it.
Family History of PCS Trait: Testing Before Pregnancy
A family history of this rare anomaly is reason to test before trying for a child, given its links to developmental disorders, infertility and inheritance.
PCS Trait: Inheritance Patterns and IVF Embryo Testing
Once karyotyping shows the trait, the questions become how it passes through a family and whether IVF with embryo testing before implantation is worth weighing.
Premature Chromatid Separation Trait and PCS/MVA Syndrome
Mosaic aneuploidies and developmental abnormalities mark the wider PCS/MVA picture, and the trait is often identified while a man is investigated for infertility.
Genetic Counseling After a PCS Trait Diagnosis
Counseling turns a test result into practical choices about treatment, reproduction and monitoring, given links to infertility, developmental disorders and cancers.