Genetic Insights into Glioma Susceptibility 2: Unlocking the Code to Better Outcomes
Variants in the MAML2 gene have been linked to glioma risk and survival in a Chinese Han population, informing surveillance and treatment choices.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Glioma Susceptibility 3, CYP4F12 and Inherited Risk
A genome-wide association study tied a SNP in the CYP4F12 gene to higher glioma risk in the Han Chinese population, with imaging surveillance options outlined.
Genetic Insights into Glioma Susceptibility 7: A New Frontier in Risk Assessment
An MGMT enhancer variant, rs10764901, has been linked to reduced glioma risk by altering transcription factor binding, which helps stratify patients by risk level.
Glycogen Storage Disease IXc: PHKG2 and Liver Signs
Testing a patient's DNA for PHKG2 changes confirms GSD IXc and sets it apart from other glycogen storage diseases that share hepatomegaly and muscle weakness.
How Hemochromatosis Type 2B Is Inherited and Found
Inherited in an autosomal recessive pattern, HJV variants drive early iron loading that can scar the liver; relatives can be screened and phlebotomy started sooner.
Genetic Gateways: Exploring Hemolytic Anemia Due to Glucophosphate Isomerase Deficiency
Low enzyme activity starves red cells of energy so they break down early, bringing fatigue, pallor, jaundice and an enlarged spleen, with transfusion as supportive care.
Hereditary Antithrombin Deficiency: Harnessing Genetic Testing for Better Diagnosis and Management
SERPINC1 mutations reduce or disable antithrombin, and hereditary antithrombin deficiency raises the risk of deep vein thrombosis and pulmonary embolism.
Harnessing Genetic Testing for Hereditary Hypotrichosis with Recurrent Skin Vesicles
Sparse scalp, eyebrow and eyelash hair with recurring fluid-filled blisters marks HHRV, an ectodermal dysplasia that genetic testing separates from similar disorders.