MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Single nucleotide polymorphisms in the HAND2 promoter may alter transcription factor binding and raise VSD2 risk, which shapes testing and genetic counseling.
Among the subtypes of this congenital heart defect, VSD3 has notable genetic implications: prenatal chromosomal testing, tailored treatment and ongoing monitoring.
Benign white, spongy lesions in the mouth can be mistaken for leukoplakia or oral lichen planus; KRT4 and KRT13 testing confirms this autosomal dominant condition.
A mutation in the WAS gene disrupts the WASP protein that immune cells depend on, producing eczema, thrombocytopenia and recurrent infections, mainly in males.
Pre- and postnatal growth retardation, distinctive facial features and skeletal differences trace to CUL7, OBSL1 or CCDC8 mutations that testing can identify.
Many people with acatalasia have no symptoms at all. The CAT gene on chromosome 11, what testing can confirm, and the cost and counseling limits involved are covered.
Developmental delays, muscle weakness and metabolic crises follow when certain fats are not broken down; naming the mutation shapes treatment and family planning.
A rare form of pustular psoriasis, ACH causes recurring pustules on the fingers and toes and nail destruction; the page reviews genetic testing and a spesolimab case.