Mannose-binding Lectin Deficiency and the MBL2 Gene
Low levels of the MBL protein leave the innate immune system less able to tag pathogens, and MBL2 variants can confirm the deficiency in infants with frequent infections.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
MEGF10-Related Myopathy: Muscle Weakness and Testing
Mutations in the MEGF10 gene bring muscle weakness and atrophy that often begin in early childhood, with testing used for diagnosis and genetic counseling.
Genetic Testing for Melanoma Susceptibility Type 8
Skin cancer risk carried in the genes is the subject here, with test results used to set surveillance intervals, sun protection advice and treatment choices.
Mysteries of Microcephaly 8: Unlocking the Genetic Code
Disrupted DNA replication follows a homozygous MCM7 mutation, limiting brain growth and causing intellectual disability in Microcephaly 8.
Mapping the Mystery: Genetic Testing and Microphthalmia, Isolated, with Coloboma 7
Where imaging and clinical exams stay inconclusive, DNA analysis can name the mutation behind MICC7's small eyes and coloboma, and clarify recurrence risk for parents.
Microphthalmia, Syndromic 11: Diagnosis and Genetics
Abnormal eye development with added syndromic features marks MCOPS11; a confirmed mutation separates it from similar syndromes and informs reproductive choices.
Genetic Testing and Its Role in Understanding Mirror Movements 2
Involuntary mirrored movement on the opposite side of the body defines this disorder; ARHGEF7, a gene in Netrin-1 axon guidance, is a candidate that testing can check.
Mysteries of Mitochondrial Hypertrophic Cardiomyopathy with Lactic Acidosis: Unraveling MTO1 Deficiency through Genetic Testing
Thickened heart muscle and lactic acidosis appear alongside hypotonia, seizures, developmental delays and optic atrophy in this disorder caused by MTO1 gene mutations.