Genetic Testing and Response to Glucocorticoid Therapy
Patients respond differently to the same corticosteroid dose, and genetic markers can flag likely responders, relapse risk in childhood ALL and dosage adjustments.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Hereditary Sensory and Autonomic Neuropathy Type 6: DST
Insensitivity to pain and temperature, blood pressure swings and digestive trouble start in infancy; DST mutations disrupt dystonin in HSAN-VI.
Hereditary Spastic Paraplegia 46: Understanding and Managing Through Genetic Testing
Leg stiffness and weakness build gradually as the corticospinal tract is affected. Confirming the causative mutation separates HSP 46 from lookalike conditions.
Harnessing Hope: Genetic Testing in Hyperekplexia 2
Unexpected noise or touch can trigger muscle stiffness and apnea in this startle disorder, and a novel GLRB mutation reported by Haq et al. helps confirm atypical cases.
Hyperekplexia 3: Harnessing Genetic Testing to Unravel a Rare Neurological Disorder
Genes for the inhibitory neurotransmitter glycine underlie this rare startle disorder; a GLRB mutation reported in a Chinese patient shows how testing pinpoints a cause.
HAPR2 (SLCO2A1): Clubbing, Periostosis, Arthritis
Both parents must pass on an SLCO2A1 change for HAPR2 to appear, disrupting prostaglandin transport and bringing digital clubbing and periostosis.
Harnessing Genetic Insights: Understanding Hypomyelinating Leukodystrophy 8 with or without Oligodontia and/or Hypogonadotropic Hypogonadism
Myelin forms poorly, sometimes alongside missing teeth and hormonal effects on sexual development. Pinpointing the mutation guides dental and hormonal care.
Hereditary Insights: Genetic Testing for Hypoplastic Left Heart Syndrome 2
Underdevelopment of the left side of the heart involves de novo mutations, copy number variations and common variants, which testing uses for risk assessment.