Amyotrophic Lateral Sclerosis Type 16: FUS Gene
Degeneration of motor neurons in ALS16 is often traced to FUS gene mutations; sequencing can confirm the subtype and guide gene-targeted research.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Arterial Calcification, Generalized, of Infancy, 2: Unraveling the Genetic Threads of a Rare Disease
Calcium deposits build up in arteries during the first months of life in GACI2. Finding ABCC6 mutations supports early diagnosis, monitoring and carrier testing.
Arthrogryposis, Distal, Type 1B: Unlocking the Genetic Code to Combat a Complex Condition
Mutations in genes for muscle and joint development leave the hands and feet contracted at birth in DA1B; testing separates it from other distal arthrogryposes.
Asphyxiating Thoracic Dystrophy 5: Unveiling the Genetic Blueprint of a Rare Disorder
Whole-exome sequencing identifies the DYNC2H1 mutations behind this constricted-ribcage ciliopathy, allowing diagnosis before severe respiratory failure sets in.
Atrial Fibrillation, Familial, 15: MYBPC3 and Screening
Genes that regulate heart rhythm, MYBPC3 among them, sit behind AFF15; family screening, tailored medication and exercise advice follow from a genetic result.
Atrial Septal Defect 8: Unraveling the Genetic Threads of Heart Health
Genetic work on ASD8 describes a TLN2 suppressor variant that softens the effects of a TPM1 mutation, feeding into diagnosis, treatment planning and counseling.
Atrial Septal Defect 9: Unveiling the Genetic Mysteries Behind a Silent Heart Anomaly
Symptoms may stay hidden until adulthood, then appear as fatigue, breathlessness or arrhythmia; PKP2 testing can identify ASD9 in newborns and at-risk relatives.
Advancing Understanding: Genetic Testing and Atrioventricular Septal Defect 4
Infants with AVSD4 may show breathing difficulty, poor weight gain and cyanosis, caused by an atrioventricular septum that fails to form and a single common valve.