Left Ventricular Noncompaction 10: Unraveling the Genetic Threads of a Complex Cardiac Condition
Spongy left ventricular muscle raises the risk of heart failure and arrhythmia; testing feeds into ICD decisions and counseling for the family.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Left Ventricular Noncompaction 7: Unlocking the Genetic Code for Better Diagnosis and Prognosis
Heart failure and arrhythmia risk drive testing here: a study of Russian patients reported 55 pathogenic variants used for prognosis and screening.
Left Ventricular Noncompaction 8: Unlocking the Genetic Code for Better Diagnosis and Management
Echocardiography and MRI may not catch LVNC8 early, while genetic screening of Russian patients identified 54 pathogenic variants, some unique to them.
Lower Motor Neuron Syndrome with Late-Adult Onset: Symptoms
Progressive muscle weakness, atrophy, cramps and gait disturbance mark this motor neuron disorder; genetic testing can identify mutations and support early diagnosis.
Lymphoproliferative Syndrome 2: EBV Risk and Testing
Infection risk, autoimmunity and lymphoma follow the abnormal lymphocyte proliferation of XLP2; SH2D1A testing and EBV reactivation monitoring are covered.
Mapping Genetic Insights: Understanding Maple Syrup Urine Disease, Mild Variant
A homozygous missense change in PPM1K underlies this milder form of MSUD; testing separates it from the classic disease and helps tailor dietary management.
Understanding Maternal Riboflavin Deficiency: The Role of Genetic Testing
Vitamin B2 demand rises during pregnancy, and a shortfall is linked to embryonic defects through ER stress-induced hepatocyte apoptosis. Metabolism genes can be tested.
Mapping the Mystery: Unraveling Meckel Syndrome, Type 11 through Genetic Testing
Renal cystic dysplasia, occipital encephalocele and extra digits arise when cilia fail; TMEM67 analysis helps confirm the diagnosis and assess recurrence risk.