Alzheimer Disease 18: Inherited Risk and Genetic Testing
Unlike sporadic Alzheimer's, Alzheimer Disease 18 is tied to inherited mutations, so DNA analysis can flag risk early; antiviral therapies remain under study.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Alzheimer Disease 19: Genetic Markers and COVID-19
Four hub genes identified after COVID-19 may act as biomarkers for AD19, informing who is monitored, how progression is predicted and which therapies are chosen.
Amelogenesis Imperfecta Hypomaturation Type 2A5: Unlocking Genetic Insights
RELT mutations have been tied to this hypomaturation subtype, where softer enamel wears and chips; testing separates it from other forms of amelogenesis imperfecta.
Amyotrophic Lateral Sclerosis Type 19: Unraveling Genetic Mysteries Through Testing
ERBB4 sits in the neuregulin-ErbB4 signaling pathway, and mutations there mark ALS19. Testing supports diagnosis, treatment planning and research.
Atrial Standstill 2: Titin Variant, Signs and Testing
Fatigue, dizziness and palpitations can follow the loss of atrial contraction in AS2; a titin missense variant, T32756I, is one reported genetic contributor.
Advancements in Understanding Auriculocondylar Syndrome 3: The Role of Genetic Testing
Ear and mandible development is affected, with severity varying widely between people. A homozygous PLCB4 missense variant and recessive inheritance are described.
AUTS2 Deficiency in Autism: Symptoms and Testing
Changes in the AUTS2 gene affect brain development and can bring language delays, intellectual disability and behavioral challenges alongside autism traits.
AEAS: Autism, Epilepsy and Joint Contractures
Developmental delays, seizures and joint contractures occur together in this rare syndrome. Genetic findings can steer anti-seizure medication and physical therapy.