Illuminating Idiopathic Bronchiectasis: The Role of Genetic Testing
Widened airways lead to repeated lung infections and poor mucus clearance; variants in the WFDC2 gene offer one genetic explanation when no other cause is found.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Illuminating Immunodeficiency 14b, Autosomal Recessive: Navigating the Genetic Maze
Loss of the MST1 protein disrupts leukocyte adhesion and T-cell development, and both parents must carry the variant for a child to be affected by this disorder.
Genetic Insights into Inherited Isolated Nail Anomaly: A Closer Look
Nail clubbing that appears without heart or lung disease has been traced to a variant in SLCO2A1, a gene involved in nail development and morphogenesis.
Inherited Obesity: Genetic Predisposition and Testing
Weight gain can be shaped by genes affecting appetite, fat storage and energy metabolism, and testing for those variants can guide diet and activity choices.
Inherited Susceptibility to Mycobacterial Diseases and STAT1
A variant in STAT1 can impair immune signaling and leave a person prone to severe, recurrent non-tuberculous mycobacterial infections that testing can help identify.
Left Ventricular Noncompaction: Unraveling the Genetic Threads of a Complex Heart Condition
Excessive muscular ridges in the left ventricle can lead to heart failure, arrhythmias and cardiac arrest, with an exon 3 ryanodine receptor deletion.
Leukodystrophy: Unraveling the Genetic Tapestry of a Complex Neurological Disorder
Loss of myelin in the brain's white matter brings motor, cognitive and developmental problems; whole exome sequencing found a common RARS1 variant in one patient group.
Understanding Li-Fraumeni Syndrome: The Role of Genetic Testing in Early Detection and Management
TP53 mutations carry a lifetime cancer risk above 90%, spanning breast cancer, sarcomas, brain tumors and adrenocortical carcinoma, and shape screening plans.