Gardner Syndrome: APC Gene, Polyps and Osteomas
An APC mutation drives colon polyps alongside osteomas, epidermoid cysts and fibromas, and carriers face a 50% chance of passing Gardner syndrome to a child.
Brandon Colby, MD
MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
About Brandon
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Education
- BA in Genetics with Honors, University of Michigan · 2000
- MD, Mount Sinai School of Medicine · 2004
- MBA, Stanford University Graduate School of Business · 2007
Affiliations & Memberships
- Affiliate Specialist, American College of Medical Genetics and Genomics (ACMG)
- Associate, American College of Preventive Medicine (ACPM)
- Member, National Society of Genetic Counselors (NSGC)
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Articles by Brandon
Harnessing the Power of Genetics: Understanding Hemochromatosis Type 2
Juvenile hemochromatosis builds iron fast from adolescence, risking liver disease, heart problems and diabetes; HJV and HAMP testing can confirm it before symptoms.
Hemoglobin D Disease: Deciphering Diagnosis Through Genetic Testing
Many people stay symptom-free while others develop mild to moderate anemia and fatigue; because blood tests can be inconclusive, beta-globin sequencing confirms it.
Hope for Hemolytic Anemia: Genetic Testing and Glutathione Reductase Deficiency
Without enough glutathione reductase, red cells lose protection from oxidative stress and break down early, bringing fatigue, pallor and jaundice.
Hereditary Hemorrhagic Telangiectasia: Harnessing Genetic Testing for Better Management
Abnormal artery-to-vein connections bring frequent nosebleeds and internal bleeding; testing for ENG and ACVRL1 mutations lets carriers be screened early for AVMs.
Hereditary Inclusion Body Myopathy-Joint Contractures-Ophthalmoplegia Syndrome: Understanding and Navigating Genetic Testing
Congenital joint contractures, external ophthalmoplegia and progressive muscle weakness define HIBM-JCOS, and DNA testing identifies the mutation behind it.
Hereditary Methemoglobinemia: Unraveling the Genetic Threads of a Rare Blood Disorder
Hemoglobin mutations such as Hb M-Hyde Park drive hereditary methemoglobinemia, lowering oxygen delivery and leaving skin blue or gray, with fatigue and headaches.
Hereditary Hurdles: Genetic Testing for Hereditary Motor and Sensory Neuropathy with Optic Atrophy
Muscle weakness, limb sensory loss and vision loss from optic atrophy occur together in HMSN-OA; genetic testing confirms it and helps predict how it progresses.