MD · MBA
Physician specializing in genetic analysis and personalized preventive medicine, and author of Outsmart Your Genes.
Brandon Colby is a physician-expert in the fields of genetic analysis and Personalized Preventive Medicine. He holds an MD from the Mount Sinai School of Medicine, an MBA from Stanford University's Graduate School of Business, and a degree in Genetics from the University of Michigan.
Dr. Colby is the author of the book Outsmart Your Genes and has developed numerous technologies that improve the analysis, interpretation, and actionability of genome sequencing data. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics (ACMG), an Associate of the American College of Preventive Medicine (ACPM), and a member of the National Society of Genetic Counselors (NSGC).
Articles by Brandon Colby, MD are reviewed for accuracy by Sequencing's medical and scientific team. This page is for informational purposes and does not constitute medical advice.
Cardiomyopathies and channelopathies underlie many cases of sudden cardiac failure in infants; gene testing can flag risk, guide treatment and inform family planning.
A triad of abnormal tall stature, intellectual disability and renal anomalies defines TSIDRAS, often traced to cytogenetic changes seen on karyotype analysis.
Growths in the thyroid range from symptom-free nodules to papillary carcinoma. Testing for BRAF, RET and RAS informs treatment choices and family risk estimates.
Whether missing teeth appear alone or with other ectodermal signs often tracks the gene involved: WNT10A in non-syndromic cases, EDA in hypohidrotic ectodermal dysplasia.
Congenital absence of one or more teeth affects oral health and facial appearance. Identifying WNT10A or EDA variants sharpens the diagnosis and shapes dental treatment.
Low transketolase activity disrupts the pentose phosphate pathway, bringing neurological deficits, lactic acidosis and developmental delays that are often missed.
Hair that cannot be tamed in childhood can have a genetic cause. Whole-exome sequencing pinpoints the UHS2 variant and separates it from other hair disorders.
Identified through a new pathogenic variant seen in two siblings, UHS3 affects hair texture; the page covers early diagnosis, care and genetic counseling.