Chain63: Colorectal Cancer

Determine predisposition for colon cancer

Example use A

Preventable measures through screening habits

Example use B

Dietary recommendations

Other uses

Identify symptoms

Developer

Dr. Colby

Genetic info

Genes	Genetic variants
MSH2	chr2:47641560,chr2:47702310,chr2:47690239
	rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668,rs6983267, rs12953717, rs4779584, rs16892766, rs3802842, rs10795668
MSH6	rs34374438,chr2:48027530,chr2:48032047,chr2:48026957,chr2:48027937,chr2:48028225,chr2:48030645,chr2:48033627,chr2:48033780,chr2:48033640,chr2:48018236,chr2:48018231,chr2:48025802,chr2:48025976,chr2:48027824,chr2:48028105,chr2:48026141,chr2:48027118
8q24	rs7014346,rs10808556,rs6983267
8q23.3	rs16892766
APC	rs1804197,chr5:112175576,rs1801166,chr5:112175211
MLH1	chr3:37045935,chr3:37090072,chr3:37070280,chr3:37092015,chr3:37059090,chr3:37090394,chr3:37053354,chr3:37090508,rs2308317,chr3:37050304
SMAD7	rs12953717
10p14	rs10795668
MLH3	rs28756987,chr14:75483796,chr14:75513339,chr14:75485594
CTNNB1	rs35288908
LOC120376	rs3802842
HMPS1	rs4779584

Qualitative

Type

text

Possible responses

INCREASED RISK, Increased Risk Detected, No Increased Risk Detected

let appChainsManager = AppChains.init(token: "<YOUR TOKEN HERE>" as String, withHostName: "api.sequencing.com")
 
appChainsManager.getReportWithApplicationMethodName("Chain63", withDatasourceId: "<FILE ID HERE>", withSuccessBlock: { (result) in
            let resultReport: Report = result as Report!
 
            if resultReport.isSucceeded() {   
                if resultReport.getResults() != nil {
                    for item: AnyObject in resultReport.getResults() {
 
                        let resultObj = item as! Result
                        let resultValue: ResultValue = resultObj.getValue()
 
                        if resultValue.getType() == ResultType.Text {
                            print(resultObj.getName() + " = " + (resultValue as! TextResultValue).getData())
                        }
                    }
                }  
            } else {
                print("Error occured while getting genetic information")
            }
 
            }) { (error) in
                print("Error occured while getting genetic information. " + error.localizedDescription)
        }

AppChains *appChains = [[AppChains alloc] initWithToken:@"<YOUR TOKEN HERE>" withHostName:@"api.sequencing.com"];
    
[appChains getReportWithApplicationMethodName:@"Chain63"
		withDatasourceId:@"<FILE ID HERE>"
		withSuccessBlock:^(Report *result) {

			for (Result *obj in [result getResults]) {
				ResultValue *frv = [obj getValue];
				if ([frv getType] == kResultTypeText) {
					NSLog(@"\nvalue %@ = %@\n", [obj getName], [(TextResultValue *)frv getData]);
				}
			}
        }
        withFailureBlock:^(NSError *error) {
        	NSLog(@"Error occured: %@", [error description]);
        }];

AppChains chains = new AppChains("<YOUR TOKEN HERE>", "api.sequencing.com");
Report result = chains.getReport("StartApp", "Chain63", "<FILE ID HERE>");
 
if (result.isSucceeded() == false)
    System.out.println("Request has failed");
else
    System.out.println("Request has succeeded");
 
for (Result r : result.getResults())
{
    ResultType type = r.getValue().getType();
 
    if (type == ResultType.TEXT)
    {
        TextResultValue v = (TextResultValue) r.getValue();
        System.out.println(String.format(" -> text result type %s = %s", r.getName(), v.getData()));
    }
}

my $chains = AppChains->new("<YOUR TOKEN HERE>", "api.sequencing.com");
my $chainsResult = $chains->getReport("StartApp", "Chain63", "<FILE ID HERE>");
 
if ($chainsResult->isSucceeded()) {
    print "Request has succeeded\n";
} else {
    print "Request has failed\n";
}
 
foreach (@{$chainsResult->getResults()})
{
    my $type = $_->getValue()->getType();
 
    if ($type == ResultType->TEXT)
    {
        my $v = $_->getValue();
        print sprintf("-> text result type %s = %s\n", $_->getName(), $v->getData());
    }
}

self.chains = AppChains('<YOUR TOKEN HERE>', 'api.sequencing.com')
chains_result = self.chains.getReport('StartApp', 'Chain63', '<FILE ID HERE>')
if chains_result.isSucceeded():
    print('Request has succeeded')
    else:
        print('Request has failed')
        for r in chains_result.getResults():
            file_type = r.getValue().getType()
            v = r.getValue()
            if file_type == 'TEXT':
                print('-> text result type {} = {}'.format(
                    r.getName(), v.getData()))

$chains = new AppChains("<YOUR TOKEN HERE>", "api.sequencing.com");
$chainsResult = $chains->getReport("StartApp", "Chain63", "<FILE ID HERE>");
 
if ($chainsResult->isSucceeded())
    echo "Request has succeeded\n";
else
    echo "Request has failed\n";
 
foreach ($chainsResult->getResults() as $r)
{
    $type = $r->getValue()->getType();
 
    switch ($type)
    {
        case ResultType::TEXT:
            $v = $r->getValue();
            echo sprintf("-> text result type %s = %s\n", $r->getName(), $v->getData());
        break;
    }
}

var chains = new AppChains("<YOUR TOKEN HERE>", "https://api.sequencing.com/v1", "https://beacon.sequencing.com/");
 
Report result = chains.GetReport("Chain63", "<FILE ID HERE>");
if (result.Succeeded == false)
    Console.WriteLine("Request has failed");
else
    Console.WriteLine("Request has succeeded");
foreach (Result r in result.getResults())
{
    ResultType type = r.getValue().getType();
 
    if (type == ResultType.TEXT)
    {
        var v = (TextResultValue) r.getValue();
        Console.WriteLine(" -> text result type {0} = {1}", r.getName(), v.Data);
    }
}